We cover email list best practices and cleaning tactics in Modules 14, 15, & 16. However, here's a quick answer:
We usually make sure that we've first sent the list 10 emails. We make sure to test different subject lines to try to gain their interest. If someone didn't open at least 1 email, we remove them from the list.
The reason we do this, is because ESPs (email service providers) start to automatically mark the emails you are sending as spam, if you keep sending people emails that they never touch.
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